Irina Stancheva, University of Edinburgh    Website

Programming DNA methylation during development

Stable patterns of gene expression during development and differentiation are achieved by sequence-specific transcription factors as well as epigenetic mechanisms that facilitate the establishment and propagation of heritable chromatin states. In the developing mouse embryo, DNA methylation is extensively reprogrammed and new patterns of DNA methylation are generated in a lineage-specific manner by de novo DNA methyltransferases DNMT3a and DNMT3b. The efficiency of this process is often supported by other proteins. In this talk I will discuss the role of chromatin remodelling ATPase LSH and G9a/GLP complex of histone methylases in developmentally programmed DNA methylation.

Myant K. et al. (2011) LSH and G9a/GLP complex are required for developmentally programmed DNA methylation. Genome Res. 21: 83-94.