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Fifth Scottish Chromatin Group Meeting
Thursday 23rd October 2008, 2-6 pm
SLT, Wellcome Trust Biocentre, University of Dundee
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Programme
14.00 - 14.45 Ana Pombo, London
Website
Transcription complexes in epigenetics and
genome function
Anas research has contributed to understanding the functional
compartmentalisation of the genome within the mammalian cell nucleus and
to unravel novel functional properties of RNA polymerase II complexes. She
is currently studying the regulation and functions of poised polymerases
in epigenetic regulation of gene expression and genome organisation,
investigating 3D genome architecture relative to functional and structural
nuclear landmarks in mammalian systems with a specific interest in
stochastic processes, and characterizing the proteome of RNA polymerase II
complexes.
Recent Publications:
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II
at bivalent genes in mouse ES cells. Nat Cell Biol. 2007 9:1428-35.
Intermingling of chromosome territories in interphase suggests role in
translocations and transcription-dependent associations. PLoS Biol. 2006
4:e138.
14.45 - 15.15 Daimark Bennett, Liverpool
Website
Epigenetic regulation by Protein Phosphatase 1 in Drosophila
15.15 - 16.15 Break - tea/coffee in atrium
16.15 - 17.30 Frank Pugh, Pennsylvania
Website
Genomic organization of chromatin and the
transcription machinery
A genome-wide understanding of gene regulation requires a detailed
knowledge of where nucleosomes, their regulators, and components of the
transcription machinery reside in relation to each other. Potential
mechanisms that define the remarkable uniformity by which nucleosomes are
organized around genes will be presented, contrasting the patterns found
in Saccharomyces vs Drosophila (and other organisms). Within
this context I will report on our progress towards high resolution maps of
where proteins that regulate chromatin and transcription are located,
including identification of sites where RNA polymerase II is rate-limited
during transcription.
Recent Publications:
Nucleosome organization in the Drosophila genome. Nature. 2008
453:358-62.
Translational and rotational settings of H2A.Z nucleosomes across the
Saccharomyces cerevisiae genome. Nature. 2007 446:572-6
17.30 - 18.00 David Lleres, Lamond Lab, Dundee.
Website
Quantitative Analysis of Chromatin Higher-Order Organization by FRET-FLIM
in living cells
18.00 - 20.00 Buffet drinks reception, WTB atrium
Organised by
Dr
Jonathan Chubb and
Prof. Tom Owen-Hughes.
This meeting was supported by
Millipore
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